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2002, Cilt 24, Sayı 2, Sayfa(lar) 064-068
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THE EFFECTS OF LONG-TERM PARENTERAL NUTRITION ON DOG PANCREAS: AN ELECTRON MICROSCOPIC STUDY
Saim ÖZDAMAR
Erciyes Üniversitesi Tıp Fakültesi Histoloji ve Embriyoloji. Doç.Dr. Kayseri
Keywords: Pancreas, Parenteral nutrition
Abstract
Purpose: The aim of this study was to examine the effects of total parenteral nutrition (TPN) on dog pancreas.

Material and Methods: Twenty-one dogs were used in this study. The dogs were divided into two groups (10 animals for control and 11 animals for experimental groups). The dogs in the experimental group were anaesthetised and the femoral vein cannulated. After a catheter was exteriorised via a subcutaneous tunnel, parenteral infusion was administered 16 hours daily for 30 days. At the end of TPN administration, the changes in the pancreatic ultrastructure and blood glucose values were evaluated and compared with the control group.

Results: There was no significant difference in the mean blood glucose level (BGL) between experimental and control groups (101.2 ± 36.3 mg% and 91.2 ± 14.3 mg%; p>0.05, respectively). Also there were no distinguishable ultrastructural differences in either exocrine or endocrine pancreases of both groups.

Conclusion: These results indicates that long term parenteral nutrition has no effects on either exocrine and endocrine pancreas.

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